The calculated distance (air line) between Angers and Issy-les-Moulineaux is approximately 160 miles respectively 258 kilometers.
By car or train, the actual journey to Issy-les-Moulineaux is certainly longer, as only the direct route (as the crow flies) between Angers and Issy-les-Moulineaux has been calculated here.
Air line (approximately)
258 kilometers
139 nautical miles