The calculated distance (air line) between Niefern-Öschelbronn and Düsseldorf is approximately 182 miles respectively 294 kilometers.
By car or train, the actual journey to Düsseldorf is certainly longer, as only the direct route (as the crow flies) between Niefern-Öschelbronn and Düsseldorf has been calculated here.
Air line (approximately)
294 kilometers
158 nautical miles