The calculated distance (air line) between Itagüí and Guadalajara de Buga is approximately 165 miles respectively 265 kilometers.
By car or train, the actual journey to Guadalajara de Buga is certainly longer, as only the direct route (as the crow flies) between Itagüí and Guadalajara de Buga has been calculated here.
Air line (approximately)
265 kilometers
143 nautical miles