The calculated distance (air line) between Itagüí and Santa Fe de Antioquia is approximately 30 miles respectively 49 kilometers.
By car or train, the actual journey to Santa Fe de Antioquia is certainly longer, as only the direct route (as the crow flies) between Itagüí and Santa Fe de Antioquia has been calculated here.
Air line (approximately)
49 kilometers
26 nautical miles