The calculated distance (air line) between Villa Elisa and San Isidro de Curuguaty is approximately 134 miles respectively 216 kilometers.
By car or train, the actual journey to San Isidro de Curuguaty is certainly longer, as only the direct route (as the crow flies) between Villa Elisa and San Isidro de Curuguaty has been calculated here.
Air line (approximately)
216 kilometers
117 nautical miles