The calculated distance (air line) between Tixtla de Guerrero and Iztapalapa is approximately 125 miles respectively 202 kilometers.
By car or train, the actual journey to Iztapalapa is certainly longer, as only the direct route (as the crow flies) between Tixtla de Guerrero and Iztapalapa has been calculated here.
Air line (approximately)
202 kilometers
109 nautical miles