The calculated distance (air line) between Tepoztlán and Iztapalapa is approximately 26 miles respectively 41 kilometers.
By car or train, the actual journey to Iztapalapa is certainly longer, as only the direct route (as the crow flies) between Tepoztlán and Iztapalapa has been calculated here.
Air line (approximately)
41 kilometers
22 nautical miles