The calculated distance (air line) between San Marcos Tlacoyalco and Iztapalapa is approximately 106 miles respectively 171 kilometers.
By car or train, the actual journey to Iztapalapa is certainly longer, as only the direct route (as the crow flies) between San Marcos Tlacoyalco and Iztapalapa has been calculated here.
Air line (approximately)
171 kilometers
92 nautical miles