The calculated distance (air line) between Santiago Ixcuintla and Tlaquepaque is approximately 147 miles respectively 237 kilometers.
By car or train, the actual journey to Tlaquepaque is certainly longer, as only the direct route (as the crow flies) between Santiago Ixcuintla and Tlaquepaque has been calculated here.
Air line (approximately)
237 kilometers
128 nautical miles