The calculated distance (air line) between San Isidro and Acapulco de Juárez is approximately 183 miles respectively 295 kilometers.
By car or train, the actual journey to Acapulco de Juárez is certainly longer, as only the direct route (as the crow flies) between San Isidro and Acapulco de Juárez has been calculated here.
Air line (approximately)
295 kilometers
159 nautical miles