The calculated distance (air line) between Mytilene and Néa Smýrni is approximately 173 miles respectively 279 kilometers.
By car or train, the actual journey to Néa Smýrni is certainly longer, as only the direct route (as the crow flies) between Mytilene and Néa Smýrni has been calculated here.
Air line (approximately)
279 kilometers
150 nautical miles