The calculated distance (air line) between Penafiel and São Domingos de Rana is approximately 182 miles respectively 293 kilometers.
By car or train, the actual journey to São Domingos de Rana is certainly longer, as only the direct route (as the crow flies) between Penafiel and São Domingos de Rana has been calculated here.
Air line (approximately)
293 kilometers
158 nautical miles