The calculated distance (air line) between Safed and Rishon LeTsiyyon is approximately 80 miles respectively 129 kilometers.
By car or train, the actual journey to Rishon LeTsiyyon is certainly longer, as only the direct route (as the crow flies) between Safed and Rishon LeTsiyyon has been calculated here.
Air line (approximately)
129 kilometers
70 nautical miles