The calculated distance (air line) between Nové Mesto nad Váhom and Humenné is approximately 186 miles respectively 300 kilometers.
By car or train, the actual journey to Humenné is certainly longer, as only the direct route (as the crow flies) between Nové Mesto nad Váhom and Humenné has been calculated here.
Air line (approximately)
300 kilometers
162 nautical miles