The calculated distance (air line) between Santa Rosa and San Isidro de Curuguaty is approximately 182 miles respectively 293 kilometers.
By car or train, the actual journey to San Isidro de Curuguaty is certainly longer, as only the direct route (as the crow flies) between Santa Rosa and San Isidro de Curuguaty has been calculated here.
Air line (approximately)
293 kilometers
158 nautical miles