The calculated distance (air line) between San Pedro de Ycuamandiyú and Ciudad del Este is approximately 184 miles respectively 296 kilometers.
By car or train, the actual journey to Ciudad del Este is certainly longer, as only the direct route (as the crow flies) between San Pedro de Ycuamandiyú and Ciudad del Este has been calculated here.
Air line (approximately)
296 kilometers
160 nautical miles