The calculated distance (air line) between San Antonio and San Isidro de Curuguaty is approximately 133 miles respectively 215 kilometers.
By car or train, the actual journey to San Isidro de Curuguaty is certainly longer, as only the direct route (as the crow flies) between San Antonio and San Isidro de Curuguaty has been calculated here.
Air line (approximately)
215 kilometers
116 nautical miles