The calculated distance (air line) between Ciudad del Este and San Isidro de Curuguaty is approximately 99 miles respectively 159 kilometers.
By car or train, the actual journey to San Isidro de Curuguaty is certainly longer, as only the direct route (as the crow flies) between Ciudad del Este and San Isidro de Curuguaty has been calculated here.
Air line (approximately)
159 kilometers
86 nautical miles