The calculated distance (air line) between Santiago de los Caballeros and Punta Cana is approximately 161 miles respectively 260 kilometers.
By car or train, the actual journey to Punta Cana is certainly longer, as only the direct route (as the crow flies) between Santiago de los Caballeros and Punta Cana has been calculated here.
Air line (approximately)
260 kilometers
140 nautical miles