The calculated distance (air line) between Salsipuedes and Santiago de los Caballeros is approximately 21 miles respectively 34 kilometers.
By car or train, the actual journey to Santiago de los Caballeros is certainly longer, as only the direct route (as the crow flies) between Salsipuedes and Santiago de los Caballeros has been calculated here.
Air line (approximately)
34 kilometers
18 nautical miles