The calculated distance (air line) between Heroica Ciudad de Tlaxiaco and Iztapalapa is approximately 170 miles respectively 274 kilometers.
By car or train, the actual journey to Iztapalapa is certainly longer, as only the direct route (as the crow flies) between Heroica Ciudad de Tlaxiaco and Iztapalapa has been calculated here.
Air line (approximately)
274 kilometers
148 nautical miles