The calculated distance (air line) between Iztapalapa and Acapulco de Juárez is approximately 182 miles respectively 293 kilometers.
By car or train, the actual journey to Acapulco de Juárez is certainly longer, as only the direct route (as the crow flies) between Iztapalapa and Acapulco de Juárez has been calculated here.
Air line (approximately)
293 kilometers
158 nautical miles