The calculated distance (air line) between Ciudad Nezahualcoyotl and Tlaxcala is approximately 53 miles respectively 86 kilometers.
By car or train, the actual journey to Tlaxcala is certainly longer, as only the direct route (as the crow flies) between Ciudad Nezahualcoyotl and Tlaxcala has been calculated here.
Air line (approximately)
86 kilometers
46 nautical miles