The calculated distance (air line) between Mexico City and Acapulco de Juárez is approximately 185 miles respectively 298 kilometers.
By car or train, the actual journey to Acapulco de Juárez is certainly longer, as only the direct route (as the crow flies) between Mexico City and Acapulco de Juárez has been calculated here.
Air line (approximately)
298 kilometers
161 nautical miles