The calculated distance (air line) between San Nicolás de Bari and Sancti Spíritus is approximately 169 miles respectively 271 kilometers.
By car or train, the actual journey to Sancti Spíritus is certainly longer, as only the direct route (as the crow flies) between San Nicolás de Bari and Sancti Spíritus has been calculated here.
Air line (approximately)
271 kilometers
146 nautical miles