The calculated distance (air line) between Manzanillo and Sancti Spíritus is approximately 186 miles respectively 299 kilometers.
By car or train, the actual journey to Sancti Spíritus is certainly longer, as only the direct route (as the crow flies) between Manzanillo and Sancti Spíritus has been calculated here.
Air line (approximately)
299 kilometers
161 nautical miles