The calculated distance (air line) between Holguín and Ciego de Ávila is approximately 174 miles respectively 280 kilometers.
By car or train, the actual journey to Ciego de Ávila is certainly longer, as only the direct route (as the crow flies) between Holguín and Ciego de Ávila has been calculated here.
Air line (approximately)
280 kilometers
151 nautical miles