The calculated distance (air line) between Esmeralda and Sancti Spíritus is approximately 85 miles respectively 137 kilometers.
By car or train, the actual journey to Sancti Spíritus is certainly longer, as only the direct route (as the crow flies) between Esmeralda and Sancti Spíritus has been calculated here.
Air line (approximately)
137 kilometers
74 nautical miles