The calculated distance (air line) between Melchor de Mencos and Chiquimula is approximately 159 miles respectively 255 kilometers.
By car or train, the actual journey to Chiquimula is certainly longer, as only the direct route (as the crow flies) between Melchor de Mencos and Chiquimula has been calculated here.
Air line (approximately)
255 kilometers
138 nautical miles