The calculated distance (air line) between Comayagua and Santa Cruz de Yojoa is approximately 40 miles respectively 65 kilometers.
By car or train, the actual journey to Santa Cruz de Yojoa is certainly longer, as only the direct route (as the crow flies) between Comayagua and Santa Cruz de Yojoa has been calculated here.
Air line (approximately)
65 kilometers
35 nautical miles