The calculated distance (air line) between Cuenca and Santo Domingo de los Colorados is approximately 183 miles respectively 295 kilometers.
By car or train, the actual journey to Santo Domingo de los Colorados is certainly longer, as only the direct route (as the crow flies) between Cuenca and Santo Domingo de los Colorados has been calculated here.
Air line (approximately)
295 kilometers
159 nautical miles