The calculated distance (air line) between Guayaquil and Santo Domingo de los Colorados is approximately 143 miles respectively 230 kilometers.
By car or train, the actual journey to Santo Domingo de los Colorados is certainly longer, as only the direct route (as the crow flies) between Guayaquil and Santo Domingo de los Colorados has been calculated here.
Air line (approximately)
230 kilometers
124 nautical miles