The calculated distance (air line) between San Pedro Cholula and Acapulco de Juárez is approximately 169 miles respectively 272 kilometers.
By car or train, the actual journey to Acapulco de Juárez is certainly longer, as only the direct route (as the crow flies) between San Pedro Cholula and Acapulco de Juárez has been calculated here.
Air line (approximately)
272 kilometers
147 nautical miles