The calculated distance (air line) between Santiago Tangamandapio and San Luis Potosí is approximately 178 miles respectively 287 kilometers.
By car or train, the actual journey to San Luis Potosí is certainly longer, as only the direct route (as the crow flies) between Santiago Tangamandapio and San Luis Potosí has been calculated here.
Air line (approximately)
287 kilometers
155 nautical miles