The calculated distance (air line) between Panindícuaro and Iztapalapa is approximately 181 miles respectively 291 kilometers.
By car or train, the actual journey to Iztapalapa is certainly longer, as only the direct route (as the crow flies) between Panindícuaro and Iztapalapa has been calculated here.
Air line (approximately)
291 kilometers
157 nautical miles