The calculated distance (air line) between San Nicolás Guadalupe and Iztapalapa is approximately 66 miles respectively 106 kilometers.
By car or train, the actual journey to Iztapalapa is certainly longer, as only the direct route (as the crow flies) between San Nicolás Guadalupe and Iztapalapa has been calculated here.
Air line (approximately)
106 kilometers
57 nautical miles