The calculated distance (air line) between Santa María Zacatepec and Iztapalapa is approximately 48 miles respectively 78 kilometers.
By car or train, the actual journey to Iztapalapa is certainly longer, as only the direct route (as the crow flies) between Santa María Zacatepec and Iztapalapa has been calculated here.
Air line (approximately)
78 kilometers
42 nautical miles