The calculated distance (air line) between Ishtixon Shahri and Shahrisabz is approximately 65 miles respectively 105 kilometers.
By car or train, the actual journey to Shahrisabz is certainly longer, as only the direct route (as the crow flies) between Ishtixon Shahri and Shahrisabz has been calculated here.
Air line (approximately)
105 kilometers
57 nautical miles