The calculated distance (air line) between Şāfītā and Khān Shaykhūn is approximately 52 miles respectively 84 kilometers.
By car or train, the actual journey to Khān Shaykhūn is certainly longer, as only the direct route (as the crow flies) between Şāfītā and Khān Shaykhūn has been calculated here.
Air line (approximately)
84 kilometers
46 nautical miles