The calculated distance (air line) between Manbij and Khān Shaykhūn is approximately 105 miles respectively 168 kilometers.
By car or train, the actual journey to Khān Shaykhūn is certainly longer, as only the direct route (as the crow flies) between Manbij and Khān Shaykhūn has been calculated here.
Air line (approximately)
168 kilometers
91 nautical miles