The calculated distance (air line) between Homs and Khān Shaykhūn is approximately 50 miles respectively 80 kilometers.
By car or train, the actual journey to Khān Shaykhūn is certainly longer, as only the direct route (as the crow flies) between Homs and Khān Shaykhūn has been calculated here.
Air line (approximately)
80 kilometers
43 nautical miles