The calculated distance (air line) between Szekszárd and Nyíregyháza is approximately 180 miles respectively 289 kilometers.
By car or train, the actual journey to Nyíregyháza is certainly longer, as only the direct route (as the crow flies) between Szekszárd and Nyíregyháza has been calculated here.
Air line (approximately)
289 kilometers
156 nautical miles