The calculated distance (air line) between Nový Bydžov and Karlovy Vary is approximately 116 miles respectively 186 kilometers.
By car or train, the actual journey to Karlovy Vary is certainly longer, as only the direct route (as the crow flies) between Nový Bydžov and Karlovy Vary has been calculated here.
Air line (approximately)
186 kilometers
101 nautical miles