The calculated distance (air line) between Nové Město na Moravě and Karlovy Vary is approximately 150 miles respectively 241 kilometers.
By car or train, the actual journey to Karlovy Vary is certainly longer, as only the direct route (as the crow flies) between Nové Město na Moravě and Karlovy Vary has been calculated here.
Air line (approximately)
241 kilometers
130 nautical miles