The calculated distance (air line) between Bystřice nad Pernštejnem and Karlovy Vary is approximately 159 miles respectively 255 kilometers.
By car or train, the actual journey to Karlovy Vary is certainly longer, as only the direct route (as the crow flies) between Bystřice nad Pernštejnem and Karlovy Vary has been calculated here.
Air line (approximately)
255 kilometers
138 nautical miles