The calculated distance (air line) between Santa Cruz de El Seibo and Santiago de los Caballeros is approximately 118 miles respectively 190 kilometers.
By car or train, the actual journey to Santiago de los Caballeros is certainly longer, as only the direct route (as the crow flies) between Santa Cruz de El Seibo and Santiago de los Caballeros has been calculated here.
Air line (approximately)
190 kilometers
103 nautical miles