The calculated distance (air line) between Santa Cruz de El Seibo and Punta Cana is approximately 43 miles respectively 70 kilometers.
By car or train, the actual journey to Punta Cana is certainly longer, as only the direct route (as the crow flies) between Santa Cruz de El Seibo and Punta Cana has been calculated here.
Air line (approximately)
70 kilometers
38 nautical miles