The calculated distance (air line) between Quemado de Güines and Sancti Spíritus is approximately 79 miles respectively 127 kilometers.
By car or train, the actual journey to Sancti Spíritus is certainly longer, as only the direct route (as the crow flies) between Quemado de Güines and Sancti Spíritus has been calculated here.
Air line (approximately)
127 kilometers
68 nautical miles