The calculated distance (air line) between Manicaragua and San Miguel del Padrón is approximately 163 miles respectively 263 kilometers.
By car or train, the actual journey to San Miguel del Padrón is certainly longer, as only the direct route (as the crow flies) between Manicaragua and San Miguel del Padrón has been calculated here.
Air line (approximately)
263 kilometers
142 nautical miles