The calculated distance (air line) between Manicaragua and Sancti Spíritus is approximately 38 miles respectively 60 kilometers.
By car or train, the actual journey to Sancti Spíritus is certainly longer, as only the direct route (as the crow flies) between Manicaragua and Sancti Spíritus has been calculated here.
Air line (approximately)
60 kilometers
33 nautical miles